| 3. Round | 08/03/2025 | Seattle Sounders | - | Los Angeles FC | 5:2 | ||||
| 4. Round | 16/03/2025 | St. Louis City SC | - | Seattle Sounders | 1:0 | ||||
| 5. Round | 23/03/2025 | Seattle Sounders | - | Houston Dynamo | 0:0 | ||||
| 6. Round | 30/03/2025 | San Jose Earthquakes | - | Seattle Sounders | 1:1 | ||||
| 7. Round | 06/04/2025 | San Diego FC | - | Seattle Sounders | 3:0 | ||||
| 8. Round | 13/04/2025 | FC Dallas | - | Seattle Sounders | 0:1 |  |
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| 9. Round | 20/04/2025 | Seattle Sounders | - | Nashville SC | 3:0 | |
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| 10. Round | 27/04/2025 | Colorado Rapids | - | Seattle Sounders | 1:1 | |
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| 11. Round | 04/05/2025 | Seattle Sounders | - | St. Louis City SC | 4:1 | |
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| 12. Round | 11/05/2025 | Houston Dynamo | - | Seattle Sounders | 1:3 | |
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| 13. Round | 15/05/2025 | Los Angeles FC | - | Seattle Sounders | 4:0 | ||||
| 14. Round | 18/05/2025 | Portland Timbers | - | Seattle Sounders | 1:1 | ||||
| 16. Round | 29/05/2025 | Seattle Sounders | - | San Diego FC | 1:0 | ||||
| 17. Round | 01/06/2025 | Seattle Sounders | - | Minnesota United FC | 2:3 | |
USA
North Macedonia