| 1. Round | 08/08/2021 | VVV-Venlo | - | NAC Breda | 2:2 | ||||
| 2. Round | 13/08/2021 | TOP Oss | - | VVV-Venlo | 2:1 |  |
|||
| 3. Round | 21/08/2021 | VVV-Venlo | - | Almere City FC | 2:1 | ||||
| 4. Round | 27/08/2021 | VVV-Venlo | - | AZ Alkmaar (J) | 0:1 | ||||
| 5. Round | 05/09/2021 | FC Dordrecht | - | VVV-Venlo | 0:1 | ||||
| 9. Round | 01/10/2021 | Jong PSV | - | VVV-Venlo | 2:1 | ||||
| 10. Round | 09/10/2021 | VVV-Venlo | - | MVV | 2:0 | |
|||
| 11. Round | 15/10/2021 | SBV Excelsior | - | VVV-Venlo | 3:0 | |
|||
| 12. Round | 22/10/2021 | VVV-Venlo | - | De Graafschap | 1:2 | ||||
| 14. Round | 05/11/2021 | VVV-Venlo | - | Jong Ajax | 1:3 | ||||
| 15. Round | 14/11/2021 | ADO Den Haag | - | VVV-Venlo | 2:0 | ||||
| 16. Round | 19/11/2021 | VVV-Venlo | - | FC Eindhoven | 2:0 | ||||
| 17. Round | 26/11/2021 | Roda JC Kerkrade | - | VVV-Venlo | 0:0 |
Netherlands