| 1. Round | 24/07/2010 | FC Biel/Bienne | - | FC Wil 1900 | 1:1 | ||||
| 2. Round | 02/08/2010 | FC Wil 1900 | - | FC Lausanne-Sport | 0:2 | ||||
| 4. Round | 14/08/2010 | FC Stade Nyonnais | - | FC Wil 1900 | 0:3 | ||||
| 3. Round | 19/08/2010 | FC Wil 1900 | - | FC Vaduz | 1:2 | ||||
| 5. Round | 23/08/2010 | FC Wil 1900 | - | FC Wohlen | 0:3 | ||||
| 6. Round | 28/08/2010 | Servette FC | - | FC Wil 1900 | 2:0 |  |
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| 7. Round | 11/09/2010 | FC Wil 1900 | - | SC Kriens | 2:1 | ||||
| 8. Round | 25/09/2010 | FC Locarno | - | FC Wil 1900 | 1:1 |  |
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| 9. Round | 02/10/2010 | FC Wil 1900 | - | FC Chiasso | 1:2 | |
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| 10. Round | 24/10/2010 | FC Aarau | - | FC Wil 1900 | 1:2 | |
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| 11. Round | 30/10/2010 | Yverdon Sport FC | - | FC Wil 1900 | 0:2 | |
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| 12. Round | 07/11/2010 | FC Wil 1900 | - | FC Lugano | 2:1 | |
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| 13. Round | 14/11/2010 | FC Winterthur | - | FC Wil 1900 | 3:1 | ||||
| 14. Round | 28/11/2010 | SR Delémont | - | FC Wil 1900 | 1:0 | ||||
| 15. Round | 05/12/2010 | FC Wil 1900 | - | FC Schaffhausen | 2:1 | |
Paraguay