| 3. Round | 07/08/2021 | Chernomorets Novorossisk | - | Spartak Nalchik | 1:1 |  |
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| 4. Round | 15/08/2021 | Spartak Nalchik | - | FK Yessentuki | 2:1 | ||||
| 5. Round | 18/08/2021 | FK Biolog Novokubansk | - | Spartak Nalchik | 1:0 | ||||
| 7. Round | 04/09/2021 | FK Mashuk KMV | - | Spartak Nalchik | 1:2 | ||||
| 9. Round | 12/09/2021 | Spartak Nalchik | - | FK Chayka | 1:0 | |
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| 10. Round | 18/09/2021 | Anzhi Makhachkala | - | Spartak Nalchik | 2:0 | ||||
| 11. Round | 26/09/2021 | Spartak Nalchik | - | FK Druzhba | 0:0 | |
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| 12. Round | 03/10/2021 | Alania-2 Vladikavkaz | - | Spartak Nalchik | 1:5 | ||||
| 14. Round | 17/10/2021 | Forte Taganrog | - | Spartak Nalchik | 0:0 | |
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| 16. Round | 31/10/2021 | Rotor-2 Volgograd | - | Spartak Nalchik | 0:3 | ||||
| 17. Round | 05/11/2021 | Spartak Nalchik | - | FK Tuapse | 1:1 | |
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| 18. Round | 13/11/2021 | Dinamo Stavropol | - | Spartak Nalchik | 0:0 | ||||
| 19. Round | 19/11/2021 | Spartak Nalchik | - | Chernomorets Novorossisk | 1:0 |
Russia