| 2. Round | 02/08/2021 | Anzhi Makhachkala | - | FK Tuapse | 1:0 | ||||
| 3. Round | 07/08/2021 | FK Tuapse | - | FK Druzhba | 3:0 |  |
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| 4. Round | 15/08/2021 | FK Tuapse | - | Alania-2 Vladikavkaz | 3:1 |  |
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| 5. Round | 20/08/2021 | FK Tuapse | - | Kuban-Holding Pavlovskaya | 0:3 dec. | |
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| 6. Round | 29/08/2021 | Forte Taganrog | - | FK Tuapse | 3:0 | ||||
| 7. Round | 04/09/2021 | FK Tuapse | - | FK Dinamo Makhachkala | 0:1 | ||||
| 8. Round | 08/09/2021 | Rotor-2 Volgograd | - | FK Tuapse | 0:1 | ||||
| 10. Round | 20/09/2021 | FK Tuapse | - | FK SKA Rostov | 0:3 dec. | ||||
| 11. Round | 26/09/2021 | Dinamo Stavropol | - | FK Tuapse | 5:1 | ||||
| 13. Round | 11/10/2021 | FK Yessentuki | - | FK Tuapse | 1:4 | ||||
| 14. Round | 18/10/2021 | FK Tuapse | - | FK Biolog Novokubansk | 0:3 dec. | ||||
| 15. Round | 23/10/2021 | FK Legion Dynamo Makhachkala | - | FK Tuapse | 0:1 | ||||
| 16. Round | 01/11/2021 | FK Tuapse | - | FK Mashuk KMV | 3:0 | ||||
| 17. Round | 05/11/2021 | Spartak Nalchik | - | FK Tuapse | 1:1 |  |
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| 19. Round | 19/11/2021 | FK Druzhba | - | FK Tuapse | 1:0 | |
Russia