| 2. Round | 26/08/2000 | Go Ahead Eagles | - | VVV | 2:1 | ||||
| 3. Round | 04/09/2000 | VVV | - | BV Emmen | 0:1 | ||||
| 4. Round | 09/09/2000 | Dordrecht '90 | - | VVV | 1:4 | ||||
| 8. Round | 14/10/2000 | SC Cambuur | - | VVV | 3:1 | ||||
| 11. Round | 04/11/2000 | VVV | - | BV Veendam | 3:2 | ||||
| 12. Round | 11/11/2000 | TOP Oss | - | VVV | 3:0 | ||||
| 13. Round | 18/11/2000 | Telstar | - | VVV | 1:0 | ||||
| 16. Round | 09/12/2000 | VVV | - | SBV Excelsior | 1:2 | ||||
| 19. Round | 07/02/2001 | VVV | - | Go Ahead Eagles | 0:2 | ||||
| 20. Round | 10/02/2001 | BV Emmen | - | VVV | 1:0 | ||||
| 17. Round | 14/02/2001 | FC Den Bosch | - | VVV | 2:0 |  |
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| 21. Round | 17/02/2001 | VVV | - | SC Cambuur | 2:3 | |
Netherlands