8. Round | 12/07/2021 | Bolívar | - | Real Santa Cruz | 1:1 | ||||
9. Round | 17/07/2021 | Real Santa Cruz | - | Club Aurora | 1:1 | ||||
10. Round | 21/07/2021 | Real Tomayapo | - | Real Santa Cruz | 2:1 | ||||
11. Round | 26/07/2021 | Real Santa Cruz | - | San José | 5:0 | ||||
13. Round | 03/08/2021 | Nacional Potosí | - | Real Santa Cruz | 2:2 | ||||
15. Round | 15/08/2021 | The Strongest | - | Real Santa Cruz | 1:2 | ||||
16. Round | 20/08/2021 | Jorge Wilstermann | - | Real Santa Cruz | 5:1 | ||||
17. Round | 23/08/2021 | Real Santa Cruz | - | Atlético Palmaflor | 1:0 | ||||
25. Round | 01/11/2021 | Real Santa Cruz | - | Real Tomayapo | 2:0 | ||||
24. Round | 07/11/2021 | Club Aurora | - | Real Santa Cruz | 4:1 |