3. Round | 08/08/2021 | UANL Tigres | - | Santos Laguna | 1:1 | ||||
4. Round | 16/08/2021 | Santos Laguna | - | Deportivo Guadalajara | 0:0 | ||||
5. Round | 19/08/2021 | Santos Laguna | - | Atlas Guadalajara | 1:1 | ||||
9. Round | 20/09/2021 | Santos Laguna | - | Puebla FC | 1:1 | ||||
11. Round | 05/11/2021 | Pumas UNAM | - | Santos Laguna | 0:3 |