| 4. Round | 14/08/2021 | RFC Seraing | - | KV Oostende | 2:3 | ||||
| 5. Round | 20/08/2021 | Standard Liège | - | KV Oostende | 1:0 | ||||
| 6. Round | 29/08/2021 | KV Oostende | - | SV Zulte Waregem | 0:2 | ||||
| 7. Round | 10/09/2021 | Club Brugge KV | - | KV Oostende | 3:0 | ||||
| 14. Round | 05/11/2021 | Oud-Heverlee Leuven | - | KV Oostende | 1:0 | ||||
| 16. Round | 28/11/2021 | Royal Antwerp FC | - | KV Oostende | 3:0 | ||||
| 17. Round | 04/12/2021 | KV Oostende | - | KAS Eupen | 2:1 | ||||
| 18. Round | 10/12/2021 | Sporting Charleroi | - | KV Oostende | 1:0 | ||||
| 19. Round | 14/12/2021 | KV Oostende | - | KV Kortrijk | 0:2 | ||||
| 20. Round | 18/12/2021 | K Beerschot VA | - | KV Oostende | 0:2 | ||||
| 24. Round | 25/01/2022 | KAA Gent | - | KV Oostende | 1:1 | ||||
| 25. Round | 29/01/2022 | Cercle Brugge | - | KV Oostende | 0:1 | ||||
| 22. Round | 09/02/2022 | SV Zulte Waregem | - | KV Oostende | 0:0 |  |
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| 27. Round | 12/02/2022 | KV Mechelen | - | KV Oostende | 3:0 | ||||
| 29. Round | 26/02/2022 | KV Oostende | - | Sint-Truidense VV | 0:0 | ||||
| 30. Round | 06/03/2022 | RSC Anderlecht | - | KV Oostende | 3:0 | ||||
| 33. Round | 02/04/2022 | KV Oostende | - | RFC Seraing | 2:2 | ||||
| 34. Round | 09/04/2022 | KAS Eupen | - | KV Oostende | 0:2 |
Ghana