| 4. Round | 06/02/2022 | Gallos Blancos | - | Puebla FC | 0:2 | ||||
| 6. Round | 19/02/2022 | Gallos Blancos | - | Mazatlán FC | 2:0 | ||||
| 7. Round | 25/02/2022 | Gallos Blancos | - | Deportivo Toluca | 1:1 |  |
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| 8. Round | 02/03/2022 | CF América | - | Gallos Blancos | 1:1 | ||||
| 10. Round | 12/03/2022 | Club Necaxa | - | Gallos Blancos | 1:0 | ||||
| 11. Round | 18/03/2022 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Round | 03/04/2022 | Club León | - | Gallos Blancos | 1:1 | ||||
| 14. Round | 17/04/2022 | Santos Laguna | - | Gallos Blancos | 1:1 | ||||
| 17. Round | 30/04/2022 | Gallos Blancos | - | FC Juárez | 4:0 |
Mexico