| 5. Round | 13/10/2021 | CD Zap | - | Inter de Querétaro | 2:1 | ||||
| 6. Round | 16/10/2021 | Inter de Querétaro | - | Inter Playa | 0:0 | ||||
| 7. Round | 23/10/2021 | Inter de Querétaro | - | Montañeses FC | 0:0 | ||||
| 8. Round | 01/11/2021 | Leviatán FC | - | Inter de Querétaro | 0:3 |  |
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| 9. Round | 06/11/2021 | Inter de Querétaro | - | Sporting Canamy | 1:0 | |
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| 10. Round | 10/11/2021 | Yalmakan FC | - | Inter de Querétaro | 1:0 | ||||
| 11. Round | 13/11/2021 | Inter de Querétaro | - | Lobos ULMX | 1:1 | ||||
| 12. Round | 21/11/2021 | Reboceros de La Piedad | - | Inter de Querétaro | 1:0 |  |
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| 13. Round | 27/11/2021 | Inter de Querétaro | - | Deportivo Dongu | 3:0 |
Mexico