2. Round | 13/03/2021 | Atlético Palmaflor | - | Real Santa Cruz | 1:0 | ||||
1. Round | 28/03/2021 | Real Santa Cruz | - | Jorge Wilstermann | 0:2 | ||||
3. Round | 03/04/2021 | Real Santa Cruz | - | Always Ready | 2:3 | ||||
4. Round | 09/04/2021 | Royal Pari | - | Real Santa Cruz | 3:2 | ||||
7. Round | 07/05/2021 | Real Santa Cruz | - | Blooming | 1:0 | ||||
5. Round | 12/05/2021 | Real Santa Cruz | - | Real Potosí | 4:1 | ||||
8. Round | 12/07/2021 | Bolívar | - | Real Santa Cruz | 1:1 | ||||
9. Round | 17/07/2021 | Real Santa Cruz | - | Club Aurora | 1:1 | ||||
11. Round | 26/07/2021 | Real Santa Cruz | - | San José | 5:0 | ||||
18. Round | 14/09/2021 | Always Ready | - | Real Santa Cruz | 4:0 | ||||
25. Round | 01/11/2021 | Real Santa Cruz | - | Real Tomayapo | 2:0 | ||||
26. Round | 22/11/2021 | San José | - | Real Santa Cruz | 1:2 | ||||
27. Round | 27/11/2021 | Independiente Petrolero | - | Real Santa Cruz | 2:1 | ||||
28. Round | 01/12/2021 | Real Santa Cruz | - | Nacional Potosí | 1:1 | ||||
29. Round | 05/12/2021 | Oriente Petrolero | - | Real Santa Cruz | 2:0 | ||||
30. Round | 12/12/2021 | Real Santa Cruz | - | The Strongest | 1:0 |