| 1. Round | 04/07/2022 | CF Pachuca [U18] | - | Gallos Blancos [U18] | 2:0 |  |
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| 2. Round | 09/07/2022 | Cruz Azul [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 3. Round | 18/07/2022 | CF Pachuca [U18] | - | Mazatlán FC [U18] | 3:1 | ||||
| 4. Round | 24/07/2022 | CF Pachuca [U18] | - | Pumas UNAM [U18] | 1:1 | |
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| 5. Round | 27/07/2022 | Club Necaxa [U18] | - | CF Pachuca [U18] | 1:2 | ||||
| 6. Round | 30/07/2022 | Deportivo Guadalajara [U18] | - | CF Pachuca [U18] | 0:1 | ||||
| 7. Round | 07/08/2022 | CF Pachuca [U18] | - | UANL Tigres [U18] | 2:1 | |
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| 9. Round | 17/08/2022 | CF Pachuca [U18] | - | CF América [U18] | 1:1 | ||||
| 10. Round | 21/08/2022 | CF Pachuca [U18] | - | Club León [U18] | 0:1 | ||||
| 16. Round | 25/08/2022 | CF Pachuca [U18] | - | Atlas Guadalajara [U18] | 0:0 | ||||
| 11. Round | 28/08/2022 | Deportivo Toluca [U18] | - | CF Pachuca [U18] | 3:1 | ||||
| 8. Round | 14/09/2022 | FC Juárez [U18] | - | CF Pachuca [U18] | 1:0 | ||||
| 15. Round | 18/09/2022 | Atlético San Luis [U18] | - | CF Pachuca [U18] | 2:3 | ||||
| 17. Round | 01/10/2022 | CF Monterrey [U18] | - | CF Pachuca [U18] | 6:0 |
Mexico