| 1. Round | 18/03/2012 | Seattle Sounders | - | Toronto FC | 3:1 |  |
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| 1. Round | 24/03/2012 | Seattle Sounders | - | Houston Dynamo | 2:0 | |
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| 1. Round | 01/04/2012 | Seattle Sounders | - | San Jose Earthquakes | 0:1 | ||||
| 2. Round | 08/04/2012 | D.C. United | - | Seattle Sounders | 0:0 | ||||
| 2. Round | 14/04/2012 | Seattle Sounders | - | Colorado Rapids | 1:0 | ||||
| 2. Round | 29/04/2012 | Chicago Fire | - | Seattle Sounders | 1:2 |  |
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| 3. Round | 03/05/2012 | Seattle Sounders | - | Los Angeles Galaxy | 2:0 | ||||
| 3. Round | 05/05/2012 | Seattle Sounders | - | Philadelphia Union | 1:0 | ||||
| 3. Round | 10/05/2012 | FC Dallas | - | Seattle Sounders | 0:2 | ||||
| 3. Round | 13/05/2012 | Seattle Sounders | - | Real Salt Lake | 0:1 | ||||
| 3. Round | 19/05/2012 | Vancouver Whitecaps | - | Seattle Sounders | 2:2 | ||||
| 3. Round | 24/05/2012 | Seattle Sounders | - | Columbus Crew | 0:2 | ||||
| 3. Round | 27/05/2012 | CD Chivas | - | Seattle Sounders | 1:1 | |
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| 7. Round | 23/09/2012 | Seattle Sounders | - | San Jose Earthquakes | 1:2 | ||||
| 8. Round | 08/10/2012 | Seattle Sounders | - | Portland Timbers | 3:0 | ||||
| 8. Round | 18/10/2012 | Seattle Sounders | - | Real Salt Lake | 0:0 | ||||
| 8. Round | 22/10/2012 | Seattle Sounders | - | FC Dallas | 3:1 |
Mexico