1. Round | 05/02/2021 | Guaraní | - | Club Nacional | 2:2 | ||||
2. Round | 09/02/2021 | Club Nacional | - | Sol de América | 1:0 | ||||
3. Round | 14/02/2021 | Sportivo Luqueño | - | Club Nacional | 0:3 | ||||
4. Round | 21/02/2021 | Club Nacional | - | Libertad | 0:3 | ||||
14. Round | 30/04/2021 | Club Nacional | - | Guaireña FC | 1:3 | ||||
15. Round | 09/05/2021 | Cerro Porteño | - | Club Nacional | 2:2 | ||||
16. Round | 17/05/2021 | Club Nacional | - | Club Olimpia | 2:1 | ||||
17. Round | 24/05/2021 | Club Nacional | - | River Plate | 0:1 | ||||
18. Round | 31/05/2021 | 12 de Octubre de Itauguá | - | Club Nacional | 2:2 |