1. Round | 04/02/2022 | Sol de América | - | Club Nacional | 0:0 | ||||
2. Round | 13/02/2022 | Club Nacional | - | Cerro Porteño | 2:3 | ||||
3. Round | 18/02/2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
4. Round | 25/02/2022 | Club Nacional | - | 12 de Octubre de Itauguá | 2:2 | ||||
5. Round | 04/03/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
7. Round | 21/03/2022 | Tacuary | - | Club Nacional | 2:1 | ||||
8. Round | 03/04/2022 | Club Nacional | - | Sportivo Ameliano | 2:1 | ||||
9. Round | 09/04/2022 | Club Olimpia | - | Club Nacional | 1:2 | ||||
10. Round | 17/04/2022 | Guaraní | - | Club Nacional | 0:1 | ||||
11. Round | 20/04/2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
12. Round | 26/04/2022 | Club Nacional | - | Sol de América | 0:3 | ||||
13. Round | 01/05/2022 | Cerro Porteño | - | Club Nacional | 1:0 | ||||
14. Round | 06/05/2022 | Club Nacional | - | Resistencia SC | 1:2 | ||||
16. Round | 14/05/2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
17. Round | 23/05/2022 | Libertad | - | Club Nacional | 1:0 | ||||
18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 | ||||
19. Round | 18/06/2022 | Sportivo Ameliano | - | Club Nacional | 2:2 | ||||
20. Round | 23/06/2022 | Club Nacional | - | Club Olimpia | 1:1 |