| 12. Round | 10/04/2005 | Atlante | - | Santos Laguna | 3:0 |  |
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| 13. Round | 17/04/2005 | Santos Laguna | - | CF Pachuca | 2:0 | ||||
| 14. Round | 21/04/2005 | Deportivo Toluca | - | Santos Laguna | 2:0 | ||||
| 15. Round | 24/04/2005 | Santos Laguna | - | Veracruz (old) | 4:1 | ||||
| 16. Round | 01/05/2005 | UANL Tigres | - | Santos Laguna | 3:1 |
Mexico