| 2. Round | 10/02/2018 | Libertad | - | Guaraní | 2:0 | ||||
| 3. Round | 16/02/2018 | Deportivo Santaní | - | Libertad | 1:2 |  |
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| 4. Round | 23/02/2018 | Libertad | - | Cerro Porteño | 1:1 | ||||
| 5. Round | 04/03/2018 | 3 de Febrero | - | Libertad | 1:4 | |
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| 6. Round | 09/03/2018 | Libertad | - | Sol de América | 1:2 | ||||
| 10. Round | 29/03/2018 | Independiente CG | - | Libertad | 3:1 |  |
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| 11. Round | 08/04/2018 | Libertad | - | General Díaz | 1:0 | ||||
| 9. Round | 12/04/2018 | Libertad | - | Club Olimpia | 0:1 | ||||
| 12. Round | 15/04/2018 | Libertad | - | Sportivo Luqueño | 1:2 | ||||
| 13. Round | 22/04/2018 | Guaraní | - | Libertad | 0:2 | ||||
| 14. Round | 30/04/2018 | Libertad | - | Deportivo Santaní | 1:1 | ||||
| 16. Round | 11/05/2018 | Libertad | - | 3 de Febrero | 2:0 | ||||
| 19. Round | 27/05/2018 | Libertad | - | Deportivo Capiatá | 3:2 | ||||
| 20. Round | 31/05/2018 | Club Olimpia | - | Libertad | 2:1 | |
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| 22. Round | 09/06/2018 | General Díaz | - | Libertad | 0:2 |
Paraguay