9. Round | 11/04/2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
10. Round | 17/04/2022 | Guaireña FC | - | Sportivo Ameliano | 2:1 | ||||
11. Round | 20/04/2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
12. Round | 25/04/2022 | Guaraní | - | Guaireña FC | 2:1 | ||||
13. Round | 02/05/2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
17. Round | 30/05/2022 | 12 de Octubre de Itauguá | - | Guaireña FC | 0:4 | ||||
18. Round | 12/06/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
19. Round | 18/06/2022 | Libertad | - | Guaireña FC | 2:0 | ||||
22. Round | 01/07/2022 | Guaireña FC | - | Club Nacional | 1:1 |