| 4. Round | 05/08/2022 | AS Trenčín | - | MFK Zemplín Michalovce | 3:1 | ||||
| 5. Round | 14/08/2022 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:4 | ||||
| 7. Round | 26/08/2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:0 | ||||
| 8. Round | 31/08/2022 | MFK Zemplín Michalovce | - | MFK Ružomberok | 1:1 | ||||
| 9. Round | 03/09/2022 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 | ||||
| 12. Round | 01/10/2022 | Dukla Banská Bystrica | - | MFK Zemplín Michalovce | 3:1 | ||||
| 13. Round | 08/10/2022 | MFK Zemplín Michalovce | - | Tatran Liptovský Mikuláš | 1:2 | ||||
| 16. Round | 24/11/2022 | Spartak Trnava | - | MFK Zemplín Michalovce | 4:1 |  |
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| 22. Round | 04/03/2023 | MFK Zemplín Michalovce | - | Zlaté Moravce | 0:0 |
Slovakia