| 2. Round | 15/03/2021 | Royal Pari | - | Real Tomayapo | 4:2 |  |
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| 3. Round | 03/04/2021 | Club San José | - | Royal Pari | 0:3 | ||||
| 14. Round | 10/08/2021 | Blooming | - | Royal Pari | 0:1 | ||||
| 15. Round | 16/08/2021 | Royal Pari | - | Bolívar | 1:1 | ||||
| 16. Round | 19/08/2021 | Royal Pari | - | Club Aurora | 1:0 | ||||
| 17. Round | 22/08/2021 | Real Tomayapo | - | Royal Pari | 1:4 |  |
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| 19. Round | 18/09/2021 | Real Santa Cruz | - | Royal Pari | 2:1 | ||||
| 20. Round | 23/09/2021 | Royal Pari | - | Nacional Potosí | 2:0 | |
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| 21. Round | 28/09/2021 | Oriente Petrolero | - | Royal Pari | 2:4 | ||||
| 22. Round | 19/10/2021 | Royal Pari | - | The Strongest | 0:1 | |
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| 23. Round | 23/10/2021 | Jorge Wilstermann | - | Royal Pari | 4:1 | ||||
| 24. Round | 28/10/2021 | Royal Pari | - | Atlético Palmaflor | 2:2 | ||||
| 27. Round | 28/11/2021 | Royal Pari | - | Real Potosí | 5:0 | |
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| 28. Round | 02/12/2021 | CD Guabirá | - | Royal Pari | 3:2 | ||||
| 29. Round | 05/12/2021 | Royal Pari | - | Blooming | 4:3 | |
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Bolivia