| 1. Round | 24/07/2021 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 1:5 |  |
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| 3. Round | 08/08/2021 | Pumas UNAM [U20] | - | Atlético San Luis [U20] | 5:3 | ||||
| 4. Round | 12/08/2021 | Atlético San Luis [U20] | - | Club Necaxa [U20] | 1:2 | ||||
| 6. Round | 21/08/2021 | Atlético San Luis [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 7. Round | 27/08/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 3:1 | ||||
| 8. Round | 10/09/2021 | Puebla FC [U20] | - | Atlético San Luis [U20] | 2:2 | |
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| 9. Round | 16/09/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 3:0 | ||||
| 14. Round | 21/09/2021 | FC Juárez [U20] | - | Atlético San Luis [U20] | 1:2 |  |
Mexico
USA