| 2. Round | 08/07/2022 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 7. Round | 06/08/2022 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 9. Round | 18/08/2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | ||||
| 11. Round | 28/08/2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 | ||||
| 4. Round | 22/09/2022 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 17. Round | 02/10/2022 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 2:3 |
Mexico