1. Round | 09/01/2022 | Santos Laguna [] | - | CF Monterrey [] | 2:1 | ||||
5. Round | 04/02/2022 | Atlético San Luis [] | - | Santos Laguna [] | 0:2 | ||||
6. Round | 12/02/2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | ||||
7. Round | 18/02/2022 | Club León [] | - | Santos Laguna [] | 2:2 | ||||
8. Round | 26/02/2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
11. Round | 19/03/2022 | Santos Laguna [] | - | Atlético San Luis [] | 2:2 | ||||
12. Round | 26/03/2022 | Santos Laguna [] | - | Mazatlán FC [] | 3:2 | ||||
13. Round | 02/04/2022 | CF Monterrey [] | - | Santos Laguna [] | 2:0 | ||||
18. Round | 07/05/2022 | Santos Laguna [] | - | Club León [] | 2:3 |