| 1. Round | 27/03/2022 | Espuce FC [Women] | - | Ñañas [Women] | 2:3 | ||||
| 2. Round | 03/04/2022 | Quito FC [Women] | - | Espuce FC [Women] | 1:1 | ||||
| 3. Round | 15/04/2022 | Espuce FC [Women] | - | Deportivo Cuenca [Women] | 2:0 | ||||
| 4. Round | 22/04/2022 | Emelec [Women] | - | Espuce FC [Women] | 0:3 | ||||
| 5. Round | 29/04/2022 | Espuce FC [Women] | - | Leones del Norte [Women] | 2:1 |  |
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| 6. Round | 07/05/2022 | Espuce FC [Women] | - | Dragonas IDV [Women] | 0:2 | ||||
| 7. Round | 14/05/2022 | Macará [Women] | - | Espuce FC [Women] | 0:1 | ||||
| 8. Round | 21/05/2022 | Ñañas [Women] | - | Espuce FC [Women] | 2:0 | ||||
| 9. Round | 27/05/2022 | Espuce FC [Women] | - | Quito FC [Women] | 0:0 |  |
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| 12. Round | 23/07/2022 | Leones del Norte [Women] | - | Espuce FC [Women] | 0:0 | |
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| 13. Round | 30/07/2022 | Dragonas IDV [Women] | - | Espuce FC [Women] | 4:0 | ||||
| 14. Round | 06/08/2022 | Espuce FC [Women] | - | Macará [Women] | 0:0 |
Ecuador