| 1. Round | 26/03/2022 | El Nacional [Women] | - | Guayaquil City [Women] | 2:0 | ||||
| 2. Round | 01/04/2022 | Universidad Católica [Women] | - | Guayaquil City [Women] | 5:0 | ||||
| 3. Round | 15/04/2022 | Guayaquil City [Women] | - | LDU Quito [Women] | 1:4 | ||||
| 4. Round | 23/04/2022 | Técnico Universitario [Women] | - | Guayaquil City [Women] | 0:1 | ||||
| 5. Round | 29/04/2022 | Guayaquil City [Women] | - | Barcelona [Women] | 0:2 | ||||
| 7. Round | 15/05/2022 | Guayaquil City [Women] | - | Deportivo Ibarra [Women] | 0:4 | ||||
| 8. Round | 22/05/2022 | Guayaquil City [Women] | - | El Nacional [Women] | 1:2 | ||||
| 10. Round | 03/06/2022 | LDU Quito [Women] | - | Guayaquil City [Women] | 8:0 |
Ecuador