| 3. Round | 05/09/2021 | Pieve di Lota [Youth] | - | AS Monaco [Youth] | 0:9 | ||||
| 10. Round | 24/10/2021 | SC Toulon [Youth] | - | AS Monaco [Youth] | 1:2 | ||||
| 11. Round | 14/11/2021 | AS Monaco [Youth] | - | Olympique Marseille [Youth] | 2:1 | ||||
| 14. Round | 05/12/2021 | FC Istres [Youth] | - | AS Monaco [Youth] | 0:1 | ||||
| 15. Round | 16/01/2022 | AS Monaco [Youth] | - | Pieve di Lota [Youth] | 21:0 |  |
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| 16. Round | 23/01/2022 | AS Monaco [Youth] | - | AS Saint-Étienne [Youth] | 2:1 | ||||
| 17. Round | 06/02/2022 | US Colomiers [Youth] | - | AS Monaco [Youth] | 1:1 | ||||
| 18. Round | 13/02/2022 | AS Monaco [Youth] | - | AC Ajaccio [Youth] | 3:0 | ||||
| 19. Round | 06/03/2022 | Nîmes Olympique [Youth] | - | AS Monaco [Youth] | 0:2 | ||||
| 20. Round | 13/03/2022 | AS Monaco [Youth] | - | Montpellier HSC [Youth] | 4:0 | ||||
| 21. Round | 27/03/2022 | AS Béziers [Youth] | - | AS Monaco [Youth] | 2:1 | ||||
| 23. Round | 10/04/2022 | Olympique Marseille [Youth] | - | AS Monaco [Youth] | 1:4 | ||||
| 24. Round | 16/04/2022 | AS Monaco [Youth] | - | AS Cannes [Youth] | 5:2 |
France