| 18. Round | 26/02/2022 | NK Opatija | - | NK Kustošija | 2:1 | ||||
| 19. Round | 06/03/2022 | NK BSK Bijelo Brdo | - | NK Opatija | 4:1 | ||||
| 20. Round | 12/03/2022 | NK Opatija | - | Dinamo Zagreb II | 0:0 | ||||
| 21. Round | 19/03/2022 | NK Solin | - | NK Opatija | 1:0 | ||||
| 23. Round | 09/04/2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Round | 16/04/2022 | NK Varaždin | - | NK Opatija | 4:0 | ||||
| 25. Round | 23/04/2022 | NK Opatija | - | NK Rudeš | 3:1 | ||||
| 27. Round | 06/05/2022 | NK Opatija | - | NK Sesvete | 1:1 |  |
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| 28. Round | 14/05/2022 | NK Dugopolje | - | NK Opatija | 3:2 | ||||
| 29. Round | 21/05/2022 | NK Opatija | - | NK Dubrava | 0:2 | ||||
| 30. Round | 28/05/2022 | HNK Orijent Rijeka | - | NK Opatija | 3:0 |
Austria