| 2. Round | 02/03/2025 | New England Revolution | - | Columbus Crew | 0:1 | ||||
| 4. Round | 16/03/2025 | San Diego FC | - | Columbus Crew | 1:1 | ||||
| 5. Round | 22/03/2025 | Columbus Crew | - | New York City FC | 0:0 | ||||
| 6. Round | 29/03/2025 | D.C. United | - | Columbus Crew | 1:2 | ||||
| 8. Round | 14/04/2025 | St. Louis City SC | - | Columbus Crew | 1:2 |
USA