2. Round | 22/08/2021 | FC Twente | - | AFC Ajax | 1:1 | ||||
5. Round | 19/09/2021 | Vitesse | - | FC Twente | 1:4 | ||||
8. Round | 01/10/2021 | FC Groningen | - | FC Twente | 1:1 | ||||
9. Round | 17/10/2021 | FC Twente | - | Willem II | 1:1 | ||||
10. Round | 24/10/2021 | FC Twente | - | NEC Nijmegen | 1:2 | ||||
11. Round | 30/10/2021 | PSV Eindhoven | - | FC Twente | 5:2 | ||||
13. Round | 20/11/2021 | Sparta Rotterdam | - | FC Twente | 0:1 | ||||
16. Round | 12/12/2021 | FC Twente | - | RKC Waalwijk | 2:1 | ||||
17. Round | 18/12/2021 | PEC Zwolle | - | FC Twente | 1:3 | ||||
19. Round | 15/01/2022 | FC Twente | - | sc Heerenveen | 2:0 | ||||
21. Round | 05/02/2022 | FC Twente | - | Vitesse | 3:0 | ||||
22. Round | 13/02/2022 | AFC Ajax | - | FC Twente | 5:0 | ||||
25. Round | 06/03/2022 | FC Twente | - | SC Cambuur | 1:0 | ||||
29. Round | 09/04/2022 | NEC Nijmegen | - | FC Twente | 0:2 | ||||
30. Round | 22/04/2022 | FC Twente | - | Sparta Rotterdam | 2:0 | ||||
31. Round | 30/04/2022 | Heracles Almelo | - | FC Twente | 1:1 | ||||
33. Round | 11/05/2022 | FC Twente | - | FC Groningen | 3:0 | ||||
34. Round | 15/05/2022 | Feyenoord | - | FC Twente | 1:2 |