| 1. Round | 02/08/2002 | Atlas Guadalajara | - | Santos Laguna | 1:2 | ||||
| 2. Round | 10/08/2002 | Santos Laguna | - | Gallos Blancos (old) | 0:0 | ||||
| 3. Round | 17/08/2002 | Puebla FC | - | Santos Laguna | 3:1 |  |
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| 4. Round | 24/08/2002 | Santos Laguna | - | CF América | 0:1 | ||||
| 5. Round | 30/08/2002 | Jaguares Chiapas | - | Santos Laguna | 2:0 | ||||
| 6. Round | 07/09/2002 | Santos Laguna | - | Cruz Azul | 1:3 |  |
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| 7. Round | 11/09/2002 | UAG Tecos | - | Santos Laguna | 2:1 | ||||
| 8. Round | 14/09/2002 | Santos Laguna | - | UANL Tigres | 3:1 | |
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| 9. Round | 21/09/2002 | CF Pachuca | - | Santos Laguna | 0:0 | ||||
| 10. Round | 27/09/2002 | Santos Laguna | - | Deportivo Guadalajara | 4:2 | ||||
| 15. Round | 26/10/2002 | Santos Laguna | - | Monarcas Morelia | 2:2 | |
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| 16. Round | 02/11/2002 | Pumas UNAM | - | Santos Laguna | 1:0 | ||||
| 17. Round | 09/11/2002 | Santos Laguna | - | Veracruz (old) | 4:2 | ||||
| 18. Round | 15/11/2002 | CF Monterrey | - | Santos Laguna | 0:0 | ||||
| 19. Round | 23/11/2002 | Santos Laguna | - | Deportivo Toluca | 5:2 |
Paraguay