| 1. Round | 11/01/2003 | Santos Laguna | - | Atlas Guadalajara | 3:0 | ||||
| 2. Round | 18/01/2003 | Gallos Blancos (old) | - | Santos Laguna | 1:0 | ||||
| 3. Round | 25/01/2003 | Santos Laguna | - | Puebla FC | 1:1 |  |
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| 4. Round | 01/02/2003 | CF América | - | Santos Laguna | 0:1 | |
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| 5. Round | 08/02/2003 | Santos Laguna | - | Jaguares Chiapas | 1:2 | ||||
| 6. Round | 14/02/2003 | Cruz Azul | - | Santos Laguna | 2:2 | ||||
| 7. Round | 22/02/2003 | Santos Laguna | - | UAG Tecos | 3:1 |  |
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| 8. Round | 28/02/2003 | UANL Tigres | - | Santos Laguna | 2:2 | ||||
| 9. Round | 08/03/2003 | Santos Laguna | - | CF Pachuca | 2:0 | ||||
| 10. Round | 15/03/2003 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 11. Round | 22/03/2003 | Santos Laguna | - | Real San Luis | 2:0 | |
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| 12. Round | 28/03/2003 | Atlético Cuernavaca | - | Santos Laguna | 2:3 | |
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| 13. Round | 05/04/2003 | Club Necaxa | - | Santos Laguna | 0:1 | ||||
| 14. Round | 12/04/2003 | Santos Laguna | - | Atlante | 1:0 | |
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| 16. Round | 26/04/2003 | Santos Laguna | - | Pumas UNAM | 4:1 | ||||
| 17. Round | 02/05/2003 | Veracruz (old) | - | Santos Laguna | 1:0 | ||||
| 18. Round | 10/05/2003 | Santos Laguna | - | CF Monterrey | 1:2 | |
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| 19. Round | 16/05/2003 | Deportivo Toluca | - | Santos Laguna | 4:3 | |
Paraguay