| 1. Round | 05/08/2003 | Deportivo Guadalajara | - | Santos Laguna | 2:1 |  |
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| 2. Round | 09/08/2003 | Santos Laguna | - | Club Necaxa | 1:1 | |
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| 3. Round | 16/08/2003 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 4. Round | 23/08/2003 | Santos Laguna | - | Pumas UNAM | 3:0 | ||||
| 7. Round | 13/09/2003 | UAG Tecos | - | Santos Laguna | 3:3 | ||||
| 8. Round | 19/09/2003 | Santos Laguna | - | CF Monterrey | 5:5 | ||||
| 9. Round | 23/09/2003 | CF América | - | Santos Laguna | 0:0 | |
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| 10. Round | 27/09/2003 | Santos Laguna | - | Atlas Guadalajara | 3:2 | |
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| 11. Round | 03/10/2003 | Real San Luis | - | Santos Laguna | 3:0 | ||||
| 12. Round | 11/10/2003 | Santos Laguna | - | Club Irapuato | 5:0 | ||||
| 13. Round | 18/10/2003 | Santos Laguna | - | Atlante | 2:3 | |
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| 14. Round | 22/10/2003 | Jaguares Chiapas | - | Santos Laguna | 1:1 | ||||
| 15. Round | 25/10/2003 | Santos Laguna | - | CF Pachuca | 1:2 | ||||
| 16. Round | 31/10/2003 | Monarcas Morelia | - | Santos Laguna | 2:4 |  |
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| 17. Round | 08/11/2003 | Santos Laguna | - | Gallos Blancos (old) | 2:1 | ||||
| 19. Round | 21/11/2003 | Santos Laguna | - | Deportivo Toluca | 3:2 |
Paraguay