| 2. Round | 23/01/2005 | Santos Laguna | - | Dorados de Sinaloa | 2:1 |  |
|||
| 3. Round | 30/01/2005 | CF América | - | Santos Laguna | 4:2 | ||||
| 4. Round | 06/02/2005 | Santos Laguna | - | UAG Tecos | 4:2 | |
|||
| 5. Round | 13/02/2005 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 6. Round | 19/02/2005 | Jaguares Chiapas | - | Santos Laguna | 2:0 | ||||
| 7. Round | 27/02/2005 | Santos Laguna | - | CF Monterrey | 3:1 | |
|||
| 8. Round | 06/03/2005 | Club Necaxa | - | Santos Laguna | 4:2 | |
|||
| 9. Round | 13/03/2005 | Santos Laguna | - | Monarcas Morelia | 3:1 | ||||
| 10. Round | 20/03/2005 | Deportivo Guadalajara | - | Santos Laguna | 5:1 | ||||
| 12. Round | 10/04/2005 | Atlante | - | Santos Laguna | 3:0 | ||||
| 15. Round | 24/04/2005 | Santos Laguna | - | Veracruz (old) | 4:1 | ||||
| 11. Round | 27/04/2005 | Santos Laguna | - | Pumas UNAM | 1:1 | ||||
| 16. Round | 01/05/2005 | UANL Tigres | - | Santos Laguna | 3:1 | ||||
| 17. Round | 08/05/2005 | Santos Laguna | - | Cruz Azul | 2:0 |
Paraguay