| 1. Round | 04/02/2012 | Libertad | - | Club Nacional | 1:0 | ||||
| 2. Round | 12/02/2012 | Club Nacional | - | Tacuary | 2:0 | ||||
| 3. Round | 18/02/2012 | Guaraní | - | Club Nacional | 1:3 | ||||
| 4. Round | 25/02/2012 | Club Nacional | - | Sol de América | 2:1 | ||||
| 5. Round | 03/03/2012 | Club Olimpia | - | Club Nacional | 2:1 | ||||
| 6. Round | 10/03/2012 | Club Nacional | - | Cerro Porteño | 2:0 | ||||
| 7. Round | 18/03/2012 | Sportivo Carapeguá | - | Club Nacional | 2:1 | ||||
| 9. Round | 01/04/2012 | Independiente CG | - | Club Nacional | 2:5 |  |
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| 10. Round | 07/04/2012 | Club Nacional | - | Club Rubio Ñu | 0:2 | ||||
| 11. Round | 15/04/2012 | Sportivo Luqueño | - | Club Nacional | 2:1 | ||||
| 13. Round | 23/04/2012 | Tacuary | - | Club Nacional | 0:3 | ||||
| 14. Round | 28/04/2012 | Club Nacional | - | Guaraní | 1:1 | ||||
| 15. Round | 06/05/2012 | Sol de América | - | Club Nacional | 3:2 | ||||
| 16. Round | 13/05/2012 | Club Nacional | - | Club Olimpia | 0:0 | ||||
| 12. Round | 06/06/2012 | Club Nacional | - | Libertad | 1:2 | ||||
| 20. Round | 30/06/2012 | Club Nacional | - | Independiente CG | 5:0 | ||||
| 21. Round | 04/07/2012 | Club Rubio Ñu | - | Club Nacional | 3:3 |  |
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| 22. Round | 07/07/2012 | Club Nacional | - | Sportivo Luqueño | 2:1 |
Paraguay