| 13. Round | 25/09/2021 | FK Neftekhimik | - | FK Krasnodar 2 | 4:1 | ||||
| 14. Round | 29/09/2021 | Torpedo Moskva | - | FK Neftekhimik | 1:1 | ||||
| 15. Round | 03/10/2021 | FK Neftekhimik | - | Enisey Krasnoyarsk | 2:3 | ||||
| 16. Round | 09/10/2021 | Kuban Krasnodar | - | FK Neftekhimik | 0:2 | ||||
| 17. Round | 13/10/2021 | FK Neftekhimik | - | Spartak Moskva 2 | 5:0 |  |
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| 18. Round | 17/10/2021 | Alania Vladikavkaz | - | FK Neftekhimik | 2:3 | ||||
| 19. Round | 23/10/2021 | FK Neftekhimik | - | Tekstilshchik Ivanovo | 3:1 | |
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| 21. Round | 06/11/2021 | FK Neftekhimik | - | Volgar Astrakhan | 0:1 | |
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| 22. Round | 13/11/2021 | Metallurg Lipetsk | - | FK Neftekhimik | 1:2 | ||||
| 23. Round | 17/11/2021 | FK Neftekhimik | - | Baltika Kaliningrad | 0:0 | ||||
| 25. Round | 27/11/2021 | FK Tom Tomsk | - | FK Neftekhimik | 1:1 | ||||
| 26. Round | 06/03/2022 | FK Neftekhimik | - | FK Orenburg | 2:1 | |
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| 28. Round | 19/03/2022 | FK Neftekhimik | - | Veles Moskva | 2:1 | ||||
| 29. Round | 26/03/2022 | Rotor Volgograd | - | FK Neftekhimik | 2:1 | |
Russia