| 1. Round | 13/08/2022 | 1. FSV Mainz 05 [Youth] | - | 1899 Hoffenheim [Youth] | 4:0 |  |
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| 2. Round | 21/08/2022 | FC-Astoria Walldorf [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:5 | |
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| 3. Round | 27/08/2022 | 1. FSV Mainz 05 [Youth] | - | VfB Stuttgart [Youth] | 4:3 | |
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| 4. Round | 03/09/2022 | 1. FC Nürnberg [Youth] | - | 1. FSV Mainz 05 [Youth] | 3:7 | |
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| 5. Round | 01/10/2022 | 1. FSV Mainz 05 [Youth] | - | Eintracht Frankfurt [Youth] | 3:2 | ||||
| 6. Round | 09/10/2022 | SSV Reutlingen [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:4 | |
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| 7. Round | 29/10/2022 | 1. FSV Mainz 05 [Youth] | - | FC Ingolstadt 04 [Youth] | 5:1 | |
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| 8. Round | 06/11/2022 | 1. FC Heidenheim 1846 [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:3 | ||||
| 10. Round | 19/11/2022 | 1. FSV Mainz 05 [Youth] | - | SV Darmstadt 98 [Youth] | 5:1 | |
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| 14. Round | 19/02/2023 | 1. FSV Mainz 05 [Youth] | - | TSV 1860 München [Youth] | 1:1 | |
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| 16. Round | 04/03/2023 | 1. FSV Mainz 05 [Youth] | - | Karlsruher SC [Youth] | 0:1 | ||||
| 15. Round | 08/03/2023 | SpVgg Unterhaching [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:4 | |
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| 17. Round | 11/03/2023 | Eintracht Trier [Youth] | - | 1. FSV Mainz 05 [Youth] | 0:7 | |
Germany