| 1. Round | 05/08/2022 | Willem II | - | Jong PSV | 1:1 | ||||
| 2. Round | 15/08/2022 | Jong PSV | - | FC Dordrecht | 1:0 | ||||
| 3. Round | 22/08/2022 | Jong PSV | - | Heracles Almelo | 0:3 | ||||
| 4. Round | 26/08/2022 | PEC Zwolle | - | Jong PSV | 4:2 | ||||
| 5. Round | 05/09/2022 | Jong PSV | - | TOP Oss | 0:3 | ||||
| 6. Round | 09/09/2022 | Roda JC Kerkrade | - | Jong PSV | 1:1 |  |
|||
| 8. Round | 12/09/2022 | Jong PSV | - | FC Den Bosch | 3:1 | ||||
| 7. Round | 16/09/2022 | VVV-Venlo | - | Jong PSV | 1:1 | ||||
| 9. Round | 30/09/2022 | ADO Den Haag | - | Jong PSV | 1:3 | ||||
| 10. Round | 07/10/2022 | Jong PSV | - | Telstar | 0:2 | ||||
| 11. Round | 14/10/2022 | MVV | - | Jong PSV | 1:1 | ||||
| 12. Round | 24/10/2022 | Jong PSV | - | Helmond Sport | 6:0 | ||||
| 13. Round | 28/10/2022 | FC Eindhoven | - | Jong PSV | 2:2 | ||||
| 14. Round | 07/11/2022 | Jong PSV | - | Almere City FC | 0:1 | ||||
| 15. Round | 11/11/2022 | De Graafschap | - | Jong PSV | 3:2 | ||||
| 16. Round | 17/11/2022 | Jong PSV | - | FC Utrecht (J) | 2:1 | ||||
| 17. Round | 12/12/2022 | AZ Alkmaar (J) | - | Jong PSV | 2:3 | ||||
| 18. Round | 15/12/2022 | Jong PSV | - | Jong Ajax | 2:2 | ||||
| 19. Round | 06/01/2023 | NAC Breda | - | Jong PSV | 2:1 | ||||
| 21. Round | 20/01/2023 | FC Den Bosch | - | Jong PSV | 1:0 | ||||
| 20. Round | 23/01/2023 | Jong PSV | - | VVV-Venlo | 1:2 |
Netherlands