| 15. Round | 21/02/2021 | Desna Chernigov | - | Dinamo Kiev | 1:1 |  |
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| 18. Round | 14/03/2021 | Shakhtar Donetsk | - | Desna Chernigov | 4:0 | ||||
| 19. Round | 20/03/2021 | Desna Chernigov | - | SK Dnipro-1 | 0:2 |  |
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| 20. Round | 03/04/2021 | Desna Chernigov | - | Olimpik Donetsk | 2:0 |  |
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| 21. Round | 10/04/2021 | Desna Chernigov | - | FK Oleksandriya | 4:1 | |
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| 22. Round | 17/04/2021 | FC Mynai | - | Desna Chernigov | 3:1 | ||||
| 23. Round | 24/04/2021 | FK Lviv | - | Desna Chernigov | 1:0 | ||||
| 24. Round | 01/05/2021 | Desna Chernigov | - | Kolos Kovalivka | 2:2 | ||||
| 25. Round | 05/05/2021 | Vorskla Poltava | - | Desna Chernigov | 1:1 | ||||
| 26. Round | 09/05/2021 | FK Mariupol | - | Desna Chernigov | 4:1 |
Ukraine