| 5. Round | 22/08/2021 | FK Mariupol | - | Zorya Lugansk | 3:4 |  |
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| 6. Round | 28/08/2021 | Inhulets Petrove | - | FK Mariupol | 3:0 | ||||
| 7. Round | 12/09/2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 | ||||
| 9. Round | 25/09/2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | ||||
| 10. Round | 01/10/2021 | FK Mariupol | - | Rukh Lviv | 0:2 | ||||
| 11. Round | 16/10/2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 12. Round | 23/10/2021 | NK Veres | - | FK Mariupol | 2:0 | ||||
| 14. Round | 06/11/2021 | FC Mynai | - | FK Mariupol | 0:2 | ||||
| 15. Round | 21/11/2021 | Vorskla Poltava | - | FK Mariupol | 5:1 |
Ukraine