| 1. Round | 05/02/2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
| 2. Round | 11/02/2022 | Tacuary | - | 12 de Octubre de Itauguá | 1:1 | ||||
| 4. Round | 27/02/2022 | Tacuary | - | Libertad | 0:1 | ||||
| 5. Round | 06/03/2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
| 10. Round | 19/04/2022 | Sol de América | - | Tacuary | 1:0 | ||||
| 15. Round | 11/05/2022 | Libertad | - | Tacuary | 3:0 | ||||
| 18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 | ||||
| 20. Round | 24/06/2022 | Guaireña FC | - | Tacuary | 0:0 |
Paraguay