| Round of 16 | 09/04/2021 | Real Estelí FC | - | Columbus Crew | 0:4 | ||||
| Quarter-finals | 06/05/2021 | CF Monterrey | - | Columbus Crew | 3:0 |
| Round of 16 | 09/04/2021 | Real Estelí FC | - | Columbus Crew | 0:4 | ||||
| Quarter-finals | 06/05/2021 | CF Monterrey | - | Columbus Crew | 3:0 |
| Derrick Burckley Etienne Jr. | |
| Born: | 25.11.1996 |
| Place of birth: |
Richmond, VA, 
USA |
| Nationality: |
Haiti
USA |
| Height: | 178 cm |
| Weight: | 73 kg |
| Position(s): | Left Midfielder Right Midfielder |
| Foot: | right |