| 1. Round | 10/01/2023 | Santos Laguna [Women] | - | Atlético San Luis [Women] | 2:0 |  |
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| 2. Round | 17/01/2023 | CF Monterrey [Women] | - | Santos Laguna [Women] | 2:1 | ||||
| 3. Round | 24/01/2023 | Santos Laguna [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 4. Round | 28/01/2023 | Gallos Blancos [Women] | - | Santos Laguna [Women] | 0:0 | ||||
| 5. Round | 07/02/2023 | CF Pachuca [Women] | - | Santos Laguna [Women] | 6:0 | ||||
| 6. Round | 09/02/2023 | Santos Laguna [Women] | - | CF América [Women] | 1:1 | ||||
| 12. Round | 04/04/2023 | Club Tijuana [Women] | - | Santos Laguna [Women] | 2:1 | ||||
| 13. Round | 18/04/2023 | Santos Laguna [Women] | - | FC Juárez [Women] | 3:2 | ||||
| 14. Round | 25/04/2023 | Club León [Women] | - | Santos Laguna [Women] | 1:1 | ||||
| 15. Round | 02/05/2023 | Santos Laguna [Women] | - | Cruz Azul [Women] | 1:1 | ||||
| 16. Round | 09/05/2023 | Santos Laguna [Women] | - | Puebla FC [Women] | 2:1 | ||||
| 17. Round | 13/05/2023 | UANL Tigres [Women] | - | Santos Laguna [Women] | 9:0 |
USA