| 1. Round | 13/03/2022 | San Antonio FC | - | Detroit City FC | 1:0 | ||||
| 2. Round | 03/04/2022 | San Antonio FC | - | Phoenix Rising | 0:2 | ||||
| 2. Round | 10/04/2022 | Orange County SC | - | San Antonio FC | 0:1 | ||||
| 2. Round | 17/04/2022 | San Antonio FC | - | El Paso Locomotive | 1:0 | ||||
| 2. Round | 24/04/2022 | New Mexico United | - | San Antonio FC | 0:1 | ||||
| 3. Round | 01/05/2022 | San Antonio FC | - | Monterey Bay FC | 6:0 | ||||
| 3. Round | 08/05/2022 | Phoenix Rising | - | San Antonio FC | 3:0 | ||||
| 3. Round | 15/05/2022 | Miami FC | - | San Antonio FC | 0:2 |  |
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| 4. Round | 05/06/2022 | Sacramento Republic | - | San Antonio FC | 1:0 | |
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| 4. Round | 11/06/2022 | Monterey Bay FC | - | San Antonio FC | 2:3 | |
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| 4. Round | 19/06/2022 | San Antonio FC | - | Oakland Roots | 1:1 | ||||
| 4. Round | 25/06/2022 | Colorado Springs Switchbacks | - | San Antonio FC | 0:1 | ||||
| 6. Round | 28/08/2022 | Indy Eleven | - | San Antonio FC | 1:0 | ||||
| 7. Round | 11/09/2022 | San Antonio FC | - | San Diego Loyal | 1:0 |
Jamaica