| 1. Round | 19/07/2021 | Deportivo Toluca [Women] | - | Atlas Guadalajara [Women] | 2:3 |  |
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| 2. Round | 27/07/2021 | Club Tijuana [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 3. Round | 31/07/2021 | Deportivo Toluca [Women] | - | Atlético San Luis [Women] | 1:0 | |
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| 5. Round | 14/08/2021 | Deportivo Toluca [Women] | - | FC Juárez [Women] | 1:1 | |
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| 7. Round | 31/08/2021 | UANL Tigres [Women] | - | Deportivo Toluca [Women] | 4:0 |  |
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| 8. Round | 06/09/2021 | Deportivo Toluca [Women] | - | Club Necaxa [Women] | 0:1 | ||||
| 10. Round | 28/09/2021 | Deportivo Toluca [Women] | - | Puebla FC [Women] | 1:1 | ||||
| 11. Round | 03/10/2021 | CF Pachuca [Women] | - | Deportivo Toluca [Women] | 1:1 | ||||
| 12. Round | 09/10/2021 | Deportivo Toluca [Women] | - | Santos Laguna [Women] | 1:0 | ||||
| 13. Round | 15/10/2021 | Gallos Blancos [Women] | - | Deportivo Toluca [Women] | 0:1 | ||||
| 17. Round | 19/11/2021 | Deportivo Toluca [Women] | - | Deportivo Guadalajara [Women] | 0:4 |
USA
Mexico