| 4. Round | 04/10/2020 | Apollon Smyrnis | - | AE Lárissa | 1:0 | ||||
| 5. Round | 17/10/2020 | Aris Saloniki | - | Apollon Smyrnis | 1:0 | ||||
| 9. Round | 21/11/2020 | Atromitos | - | Apollon Smyrnis | 2:2 | ||||
| 3. Round | 25/11/2020 | Asteras Tripolis | - | Apollon Smyrnis | 0:0 |  |
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| 10. Round | 30/11/2020 | Apollon Smyrnis | - | Volos NFC | 3:3 | ||||
| 11. Round | 06/12/2020 | OFI Heraklion | - | Apollon Smyrnis | 0:2 | |
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| 12. Round | 13/12/2020 | Apollon Smyrnis | - | AEK Athen | 3:4 | ||||
| 13. Round | 19/12/2020 | Panetolikos | - | Apollon Smyrnis | 0:1 | ||||
| 14. Round | 03/01/2021 | PAS Giannina | - | Apollon Smyrnis | 1:3 | ||||
| 15. Round | 06/01/2021 | Apollon Smyrnis | - | Panathinaikos | 0:1 | ||||
| 17. Round | 16/01/2021 | AE Lárissa | - | Apollon Smyrnis | 0:1 | ||||
| 19. Round | 27/01/2021 | Lamia | - | Apollon Smyrnis | 1:0 | ||||
| 20. Round | 31/01/2021 | Apollon Smyrnis | - | Olympiakos Piraeus | 1:3 | ||||
| 21. Round | 07/02/2021 | PAOK Saloniki | - | Apollon Smyrnis | 2:2 | ||||
| 23. Round | 21/02/2021 | Volos NFC | - | Apollon Smyrnis | 2:0 | ||||
| 24. Round | 27/02/2021 | Apollon Smyrnis | - | OFI Heraklion | 2:1 | ||||
| 25. Round | 08/03/2021 | AEK Athen | - | Apollon Smyrnis | 2:0 | ||||
| 26. Round | 14/03/2021 | Apollon Smyrnis | - | Panetolikos | 1:0 |
Greece