| 1. Round | 08/07/2022 | CF América [Women] | - | Deportivo Toluca [Women] | 2:1 | ||||
| 2. Round | 18/07/2022 | Deportivo Toluca [Women] | - | CF Pachuca [Women] | 3:2 |  |
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| 3. Round | 23/07/2022 | Pumas UNAM [Women] | - | Deportivo Toluca [Women] | 1:2 | ||||
| 4. Round | 29/07/2022 | Deportivo Toluca [Women] | - | Santos Laguna [Women] | 2:0 | ||||
| 5. Round | 01/08/2022 | Atlas Guadalajara [Women] | - | Deportivo Toluca [Women] | 2:2 |  |
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| 6. Round | 08/08/2022 | Deportivo Guadalajara [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 7. Round | 15/08/2022 | Deportivo Toluca [Women] | - | Cruz Azul [Women] | 2:0 | ||||
| 10. Round | 29/08/2022 | Deportivo Toluca [Women] | - | Atlético San Luis [Women] | 2:0 | ||||
| 9. Round | 06/09/2022 | CF Monterrey [Women] | - | Deportivo Toluca [Women] | 5:2 | ||||
| 11. Round | 13/09/2022 | Mazatlán FC [Women] | - | Deportivo Toluca [Women] | 3:1 | ||||
| 14. Round | 26/09/2022 | Deportivo Toluca [Women] | - | UANL Tigres [Women] | 1:4 | ||||
| 15. Round | 01/10/2022 | Club Tijuana [Women] | - | Deportivo Toluca [Women] | 1:0 | ||||
| 17. Round | 24/10/2022 | Club León [Women] | - | Deportivo Toluca [Women] | 1:2 |
Mexico