1. Round | 09/01/2022 | Santos Laguna [] | - | CF Monterrey [] | 2:1 | ||||
6. Round | 12/02/2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 | ||||
7. Round | 18/02/2022 | Club León [] | - | Santos Laguna [] | 2:2 | ||||
9. Round | 05/03/2022 | Santos Laguna [] | - | Club Tijuana [] | 2:1 | ||||
10. Round | 12/03/2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 3:0 | ||||
13. Round | 02/04/2022 | CF Monterrey [] | - | Santos Laguna [] | 2:0 | ||||
18. Round | 07/05/2022 | Santos Laguna [] | - | Club León [] | 2:3 |