| 3. Round | 14/08/1980 | 1. FC Saarbrücken | - | ESV Ingolstadt | 5:1 | ||||
| 4. Round | 18/08/1980 | Kickers Offenbach | - | 1. FC Saarbrücken | 5:1 | ||||
| 5. Round | 22/08/1980 | 1. FC Saarbrücken | - | Freiburger FC | 2:2 | ||||
| 7. Round | 04/09/1980 | 1. FC Saarbrücken | - | SpVgg Bayreuth | 0:2 | ||||
| 14. Round | 30/10/1980 | 1. FC Saarbrücken | - | SC Freiburg | 1:0 | ||||
| 16. Round | 14/11/1980 | 1. FC Saarbrücken | - | FC Augsburg | 3:0 | ||||
| 15. Round | 18/11/1980 | Hessen Kassel | - | 1. FC Saarbrücken | 0:0 | ||||
| 17. Round | 27/11/1980 | VfB Eppingen | - | 1. FC Saarbrücken | 4:0 | ||||
| 18. Round | 27/12/1980 | 1. FC Saarbrücken | - | Eintracht Trier | 1:1 | ||||
| 20. Round | 02/01/1981 | VfR Bürstadt | - | 1. FC Saarbrücken | 2:1 | ||||
| 23. Round | 09/03/1981 | 1. FC Saarbrücken | - | Kickers Offenbach | 1:4 | ||||
| 33. Round | 14/04/1981 | SC Freiburg | - | 1. FC Saarbrücken | 2:0 | ||||
| 38. Round | 29/05/1981 | 1. FC Saarbrücken | - | Borussia Neunkirchen | 2:0 |
France