| 8. Round | 24/07/2021 | Central Español | - | Villa Teresa | 2:1 | ||||
| 9. Round | 30/07/2021 | Villa Teresa | - | Atenas | 0:3 | ||||
| 10. Round | 07/08/2021 | Racing | - | Villa Teresa | 2:0 | ||||
| 11. Round | 14/08/2021 | Albion | - | Villa Teresa | 2:0 |  |
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| 15. Round | 05/10/2021 | Villa Teresa | - | Danubio | 0:2 | ||||
| 17. Round | 19/10/2021 | Villa Teresa | - | CA Cerro | 1:2 | ||||
| 18. Round | 29/10/2021 | Defensor Sporting | - | Villa Teresa | 1:2 | ||||
| 19. Round | 02/11/2021 | Villa Teresa | - | Central Español | 1:2 | ||||
| 20. Round | 09/11/2021 | Atenas | - | Villa Teresa | 0:1 | ||||
| 21. Round | 17/11/2021 | Villa Teresa | - | Racing | 0:0 | ||||
| 22. Round | 24/11/2021 | Villa Teresa | - | Albion | 1:1 |
Uruguay